What does this research mean for the field?

Ag/TiO₂ bimetallic nanoparticles synthesized using Couroupita guianensis extracts function as stable, multifunctional nanomaterials with significant anti-diabetic, anti-inflammatory, antioxidant, and antibacterial activities. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To synthesize Ag/TiO₂ bimetallic nanoparticles using Couroupita guianensis leaf and floral extracts and evaluate their computational, antidiabetic, anti-inflammatory, and antibacterial properties.

September 5, 2026Next MaterialsOpen Access

Plant-mediated fabrication of Ag/TiO₂ bimetallic nanoparticles with anti-diabetic and anti-Inflammatory activities: Computational and experimental investigation

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Authors

PGPavithra Gunaseelan SBS. Sathik Basha MHMohammad Habeeb

Discussion

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Overview

In vitro and in silico study demonstrates antidiabetic and anti-inflammatory activities of green-synthesized Ag/TiO₂ bimetallic nanoparticles, highlighting their multifunctional therapeutic potential.

Key Points

To synthesize Ag/TiO₂ bimetallic nanoparticles using Couroupita guianensis leaf and floral extracts and evaluate their computational, antidiabetic, anti-inflammatory, and antibacterial properties.
Fabricated Ag/TiO₂ nanoparticles using C. guianensis leaf and flower extracts, characterizing them via TEM, XRD, FTIR, and zeta potential analysis.
Conducted molecular docking and molecular dynamics simulations evaluating phytochemical interactions with α-amylase.
Evaluated in vitro radical scavenging, antibacterial activity against Escherichia coli and Staphylococcus aureus, α-amylase inhibition, and anti-inflammatory efficacy.
Flower-mediated nanoparticles achieved 56.87% α-amylase inhibition at 100 µg/mL compared to 50.92% for leaf-mediated nanoparticles, corroborated by computational docking scores for β-amyrin palmitate (-8.1 kcal/mol) and farnesol (-6.6 kcal/mol).
Leaf-mediated nanoparticles exhibited 73.61% anti-inflammatory efficacy at 10 µg/mL compared to 71.61% for flower-mediated nanoparticles.
TEM revealed well-dispersed spherical nanoparticles measuring 10–100 nm (leaf) and 10–95 nm (flower), with crystalline anatase and rutile phases confirmed by XRD.

Cite This Study

Gunaseelan et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3e16b95aff0620eb012 https://doi.org/10.1016/j.nxmate.2026.103359

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September 5, 2026Next MaterialsOpen Access

Plant-mediated fabrication of Ag/TiO₂ bimetallic nanoparticles with anti-diabetic and anti-Inflammatory activities: Computational and experimental investigation

View Full Paper

Ask AI

Bookmark

Authors

PGPavithra Gunaseelan SBS. Sathik Basha MHMohammad Habeeb

Discussion

Member takes

Overview

Key Points

To synthesize Ag/TiO₂ bimetallic nanoparticles using Couroupita guianensis leaf and floral extracts and evaluate their computational, antidiabetic, anti-inflammatory, and antibacterial properties.
Fabricated Ag/TiO₂ nanoparticles using C. guianensis leaf and flower extracts, characterizing them via TEM, XRD, FTIR, and zeta potential analysis.
Conducted molecular docking and molecular dynamics simulations evaluating phytochemical interactions with α-amylase.
Evaluated in vitro radical scavenging, antibacterial activity against Escherichia coli and Staphylococcus aureus, α-amylase inhibition, and anti-inflammatory efficacy.
Flower-mediated nanoparticles achieved 56.87% α-amylase inhibition at 100 µg/mL compared to 50.92% for leaf-mediated nanoparticles, corroborated by computational docking scores for β-amyrin palmitate (-8.1 kcal/mol) and farnesol (-6.6 kcal/mol).
Leaf-mediated nanoparticles exhibited 73.61% anti-inflammatory efficacy at 10 µg/mL compared to 71.61% for flower-mediated nanoparticles.
TEM revealed well-dispersed spherical nanoparticles measuring 10–100 nm (leaf) and 10–95 nm (flower), with crystalline anatase and rutile phases confirmed by XRD.

Cite This Study

Gunaseelan et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3e16b95aff0620eb012 https://doi.org/10.1016/j.nxmate.2026.103359

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