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September 5, 2026Drug DeliveryOpen Access

Sprayable NIR/pH-responsive NSC/PF127 hydrogel loaded with MoO₂, ciprofloxacin, and FGF-2 for enhanced antibacterial and pro-regenerative infected wound healing

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Authors

ZLZhirui LiMLMingxing LeiCCChen Chen

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Overview

Preclinical study demonstrates accelerated infected wound healing and tissue regeneration in rats, highlighting the therapeutic potential of multifunctional smart hydrogels.

Key Points

  • Develop and evaluate a sprayable, dual-responsive hydrogel loaded with MoO₂ nanoparticles, ciprofloxacin, and FGF-2 to eradicate persistent bacteria and stimulate tissue regeneration in infected wounds.
  • Synthesized an N-succinyl chitosan/Pluronic F127 hydrogel loaded with MoO₂ nanoparticles, ciprofloxacin, and fibroblast growth factor-2 that transitions into a gel at body temperature and responds to near-infrared light and pH changes.
  • Assessed in vitro cytocompatibility, fibroblast and keratinocyte migration, and antibacterial activity against bacterial biofilms.
  • Evaluated wound closure, inflammatory responses, collagen deposition, angiogenesis, and oxidative stress markers in a rat model of full-thickness skin wounds infected with Staphylococcus aureus.
  • Hydrogel photothermal activation combined with sustained ciprofloxacin release suppressed bacterial growth and disrupted established biofilms in vitro.
  • Treatment enhanced fibroblast and keratinocyte migration in vitro and promoted collagen deposition, angiogenesis, and reduced oxidative stress in vivo.
  • Significantly accelerated tissue regeneration and wound closure while suppressing local inflammation in Staphylococcus aureus-infected rat wounds.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3f16b95aff0620eb3e1https://doi.org/10.1080/10717544.2026.2719063
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