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September 5, 2026Headache The Journal of Head and Face Pain

How are migraine‐related stigma, psychological factors, and disability related? A cross‐sectional investigation of associational patterns

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Authors

FHFelicitas A. HuberESElizabeth K. SengEWEmily C Willroth

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Overview

Cross-sectional study reveals psychological pathways connecting stigma to migraine disability in adults, highlighting stress and pain catastrophizing as key targets.

Key Points

  • To evaluate patterns of statistical associations among perceived migraine stigma, psychological distress factors, and disability experienced both during attacks (ictal) and between attacks (interictal).
  • Conducted a web-based cross-sectional survey of N=103 American adults with active migraine between 2024 and 2025.
  • Measured perceived stigma, stress, anxiety, depression, pain catastrophizing, and ictal and interictal disability using validated instruments including MIDAS, MIBS-4, PSS-4, PHQ-9, and GAD-7.
  • Applied associational variable analysis to model bidirectional relationships between migraine-related stigma and disability domains.
  • Perceived stress partially accounted for the relationship between perceived stigma and ictal disability (effect = 0.10, 95% CI [0.01, 0.24]), whereas pain catastrophizing partially accounted for stigma's relationship with interictal disability (effect = 0.04, 95% CI [0.01, 0.09]).
  • In reversed models assessing disability predicting stigma, perceived stress accounted for variance in ictal disability (effect = 0.03, 95% CI [0.0002, 0.07]).
  • Depressive symptoms (effect = 0.25, 95% CI [0.04, 0.54]) and pain catastrophizing (effect = 0.44, 95% CI [0.11, 0.91]) partially accounted for the association between interictal disability and perceived stigma.

Cite This Study

Huber et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4046b95aff0620eb497https://doi.org/10.1111/head.70183
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Anxiety and Depression on Migraine-Related Disability: Results from the Headache Assessment via Digital Platform in the United States (HeAD-US) Study2025
  2. 2Influence of Stigma on the Diagnosis and Treatment of Migraine2024 · 1 citations
  3. 3Stress, Anxiety, Depression, and Pain Catastrophizing in Migraine: Associations with Disability and Quality of Life2026
  4. 4Migraine stigma and general knowledge of migraine: A cross-sectional European survey2025
  5. 5Underrecognition of migraine‐related stigmatizing attitudes and social burden: Results of the OVERCOME Japan study2024 · 8 citations