Experimental study demonstrates visible-light palladium catalysis for tandem radical cyclization, highlighting a mild pathway to allylated gamma-lactams.
An efficient tandem amidyl-radical cyclization/alkyl radical Heck reaction for the construction of allylated γ-lactams has been developed under visible-light-induced palladium catalysis. The reaction proceeds via an amidyl radical/Pd(I) hybrid species generated through photoexcited Pd(0)-mediated N–O bond cleavage of N-acyloxyamides, followed by intramolecular cyclization to form an alkyl–Pd(I) intermediate. This intermediate subsequently undergoes an intermolecular alkyl radical Heck reaction with vinyl arenes, furnishing N-alkyl allylated γ-lactams bearing diverse functional groups under mild conditions. Furthermore, successful late-stage functionalization of bioactive molecules and downstream transformations of the products underscore the utility of this method.
No takes yet. Share an insight, caveat, or question.
Yang et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: