What does this research mean for the field?

Endoscopic injection sclerotherapy with pre-deflation ligation (EISpdL) is a feasible and safe technique that may improve sclerosant retention and variceal thrombosis in patients with esophageal varices. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To report a modified endoscopic injection sclerotherapy technique featuring pre-deflation ligation (EISpdL) designed to improve sclerosant retention and prevent early washout.

September 5, 2026DEN OpenOpen Access

Endoscopic Injection Sclerotherapy With Pre‐deflation Ligation for Prolonged Sclerosant Retention in Esophageal Varices: A Case Report

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To report a modified endoscopic injection sclerotherapy technique featuring pre-deflation ligation (EISpdL) designed to improve sclerosant retention and prevent early washout.
Performed EISpdL combined with gel-immersion endoscopic injection sclerotherapy in a 59-year-old man with medium-sized esophageal varices (F2, RC1) and metabolic dysfunction-associated steatohepatitis.
Ligated the puncture site via endoscopic variceal ligation while keeping the endoscope balloon inflated, maintaining continuous balloon compression during the retention phase of ethanolamine oleate.
The procedure was technically feasible with standard endoscopy skills and resulted in no immediate procedure-related adverse events.
Endoscopy at day 7 demonstrated bronze-colored variceal changes confirming thrombosis, and contrast-enhanced CT at 2 months confirmed complete variceal obliteration.

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Implication

Case report demonstrates successful variceal obliteration using pre-deflation ligation during sclerotherapy in a patient with steatohepatitis, suggesting enhanced sclerosant retention.

Cite This Study

Sugawara et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4606b95aff0620ec015 https://doi.org/10.1002/deo2.70410

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Implication

Case report demonstrates successful variceal obliteration using pre-deflation ligation during sclerotherapy in a patient with steatohepatitis, suggesting enhanced sclerosant retention.

Endoscopic Injection Sclerotherapy With Pre‐deflation Ligation for Prolonged Sclerosant Retention in Esophageal Varices: A Case Report

Key Points

Discussion

Implication

Cite This Study

Endoscopic Injection Sclerotherapy With Pre‐deflation Ligation for Prolonged Sclerosant Retention in Esophageal Varices: A Case Report

Key Points

Discussion

Implication

Cite This Study

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