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Pre-registered target trial emulation reports an evaluation plan for early cisatracurium in mechanically ventilated severe hypoxemia, highlighting methods to reduce observational bias.
Pre-registered analysis protocol for a target trial emulation comparing early continuous cisatracurium versus no neuromuscular blockade in mechanically ventilated patients with severe hypoxemia (PaO₂/FiO₂ < 150) using MIMIC-IV. Protocol finalized before the confirmatory m = 50 analysis run. Version 1.1 (2026-09-02).
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Yaoqi Xu (2026) studied this question.
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