Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2026Journal of Applied Polymer ScienceOpen Access

Development of Biocellulose‐Based Bioactive Membrane Incorporating Piper betle L. Leaf Extract for Applications in Wound Healing Dressing

View Full Paper
Ask AI
Bookmark
Share

Authors

TDThuy‐Tien Ngoc DoBCBao‐Tran Thi ChauKLKien-Quoc Le

Discussion

Loading...

Member takes

Overview

In vitro study demonstrates antibacterial and anti-inflammatory activity of biocellulose-collagen dressings, suggesting potential for advanced wound care.

Key Points

  • To fabricate and evaluate an antibacterial, anti-inflammatory composite membrane composed of bacterial cellulose, fish-skin Type I collagen, and Piper betle leaf extract for wound dressing applications.
  • Fabricated composite membranes (BC/Col/PBLE) by incorporating fish-skin Type I collagen and Piper betle leaf extract into bacterial cellulose.
  • Characterized structural and physical properties using SEM, DSC, FTIR, water vapor transmission rate (WVTR), and 28-day biodegradation assays.
  • Evaluated antibacterial efficacy against Gram-positive and Gram-negative bacteria, in vitro cellular biocompatibility in RAW264.7 cells up to 5000 ppm, and anti-inflammatory activity via LPS-induced nitric oxide inhibition.
  • BC/Col/PBLE membranes exhibited an interconnected nanofibrous network, optimal skin WVTR, and achieved 65%–70% biodegradation after 28 days.
  • Membranes displayed potent antibacterial activity against both Gram-positive and Gram-negative bacteria while preserving RAW264.7 cell viability up to 5000 ppm.
  • Membranes significantly suppressed lipopolysaccharide-induced nitric oxide production, demonstrating strong anti-inflammatory effects.

Cite This Study

Do et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd48c6b95aff0620ec462https://doi.org/10.1002/app.71463
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development and characterization of a sustainable bacterial cellulose/collagen composite membrane for enhanced wound healing and tissue regeneration applications2026
  2. 2Wound Healing Application of Bacterial Cellulose Composite Films: A Comparative Study2026
  3. 3Commercial, Non-Commercial and Experimental Wound Dressings Based on Bacterial Cellulose: An In-Depth Comparative Study of Physicochemical Properties2025 · 6 citations
  4. 4Mangosteen extract-infused bacterial cellulose membranes: Characterization and antimicrobial performance for wound dressing applications2026
  5. 5Preliminary Study: Antimicrobial Permeation and Release Rates of Biocellulose Wound Dressing Produced Using Acetobacter Xylinum 0416 in Pineapple Peel Waste Culture2024