What does this research mean for the field?

Cluster, stepped-wedge, and hybrid effectiveness-implementation trial designs are critical methodological approaches for evaluating and facilitating the adoption of evidence-based practices to drive organizational change in healthcare settings. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate trial designs used in implementation science—specifically cluster, stepped-wedge, and hybrid designs—and guide the selection of appropriate methodologies for organizational change in stroke care.

September 5, 2026

Role of Clinical Trials in Implementation Science and Organization Change: An Overview of Cluster, Stepped-Wedge, and Hybrid Effectiveness-Implementation Studies.

View Full Paper

Ask AI

Bookmark

Authors

KCKelly Coughlan OFOyebola Fasugba SDSimeon Dale

Discussion

Member takes

Overview

Topical review examines trial designs for organizational practice change in stroke healthcare, highlighting methodological considerations to optimize real-world clinical translation.

Key Points

To evaluate trial designs used in implementation science—specifically cluster, stepped-wedge, and hybrid designs—and guide the selection of appropriate methodologies for organizational change in stroke care.
Reviewed core trial methodologies used to change organizational practice, specifically cluster randomized, stepped-wedge, and hybrid effectiveness-implementation designs.
Examined practical stroke healthcare case studies to evaluate design features, operational trade-offs, and real-world application.
Characterized the unique structural features, trade-offs, and methodological requirements of cluster, stepped-wedge, and hybrid trial designs in health systems.
Illustrated through stroke research case studies that tailored design selection effectively supports the uptake of evidence-based practices and establishes sustainable healthcare processes.

Cite This Study

Coughlan et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd48c6b95aff0620ec570 https://doi.org/10.1161/strokeaha.125.052073

View Full Paper

Ask AI

Bookmark

September 5, 2026

Role of Clinical Trials in Implementation Science and Organization Change: An Overview of Cluster, Stepped-Wedge, and Hybrid Effectiveness-Implementation Studies.

View Full Paper

Ask AI

Bookmark

Authors

KCKelly Coughlan OFOyebola Fasugba SDSimeon Dale

Discussion

Member takes

Overview

Topical review examines trial designs for organizational practice change in stroke healthcare, highlighting methodological considerations to optimize real-world clinical translation.

Key Points

To evaluate trial designs used in implementation science—specifically cluster, stepped-wedge, and hybrid designs—and guide the selection of appropriate methodologies for organizational change in stroke care.
Reviewed core trial methodologies used to change organizational practice, specifically cluster randomized, stepped-wedge, and hybrid effectiveness-implementation designs.
Examined practical stroke healthcare case studies to evaluate design features, operational trade-offs, and real-world application.
Characterized the unique structural features, trade-offs, and methodological requirements of cluster, stepped-wedge, and hybrid trial designs in health systems.
Illustrated through stroke research case studies that tailored design selection effectively supports the uptake of evidence-based practices and establishes sustainable healthcare processes.

Cite This Study

Coughlan et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd48c6b95aff0620ec570 https://doi.org/10.1161/strokeaha.125.052073

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark