What does this research mean for the field?

Transgender individuals pursuing gender-affirming care follow distinct, heterogeneous transition pathways—such as fertility preservation, mixed medical transition, or minimal medical intervention—rather than a uniform clinical trajectory. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

To investigate whether gender-affirming medical, reproductive, and legal interventions cluster into distinct transition pathways in a real-world clinical setting.

September 5, 2026International Journal of Transgender HealthOpen Access

Beyond a uniform transition: Distinct pathways of gender-affirming care in a multidisciplinary gender clinic

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Authors

SMShir Maoz SYShani Yaakobi-Zelnik EYEkaterina Yovanovich

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Overview

Retrospective cohort study reveals distinct transition pathways in transgender individuals, highlighting the need for individualized, flexible gender-affirming care.

Key Points

To investigate whether gender-affirming medical, reproductive, and legal interventions cluster into distinct transition pathways in a real-world clinical setting.
Retrospective cohort study analyzing clinical records of N=401 adult transgender individuals attending a hospital-based multidisciplinary gender clinic in Israel between 2020 and 2025.
Conducted latent class analysis to identify transition pathways using indicators for fertility preservation, gender-affirming chest surgery, and legal gender marker changes.
Identified three distinct classes: Minimal Medical Intervention Pathway (43.14%), Mixed Medical Transition Pathway (33.17%), and Fertility Preservation Pathway (23.69%).
The Fertility Preservation Pathway was associated with younger initiation age and a transfeminine majority, while the Mixed Medical Transition Pathway had higher transmasculine representation, and the Minimal Medical Intervention Pathway had the highest proportion of nonbinary individuals.
No statistically significant differences were observed across the three transition pathways regarding psychiatric comorbidities.

Cite This Study

Maoz et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd49d6b95aff0620ec642 https://doi.org/10.1080/26895269.2026.2725892

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September 5, 2026International Journal of Transgender HealthOpen Access

Beyond a uniform transition: Distinct pathways of gender-affirming care in a multidisciplinary gender clinic

View Full Paper

Ask AI

Bookmark

Authors

SMShir Maoz SYShani Yaakobi-Zelnik EYEkaterina Yovanovich

Discussion

Member takes

Overview

Retrospective cohort study reveals distinct transition pathways in transgender individuals, highlighting the need for individualized, flexible gender-affirming care.

Key Points

To investigate whether gender-affirming medical, reproductive, and legal interventions cluster into distinct transition pathways in a real-world clinical setting.
Retrospective cohort study analyzing clinical records of N=401 adult transgender individuals attending a hospital-based multidisciplinary gender clinic in Israel between 2020 and 2025.
Conducted latent class analysis to identify transition pathways using indicators for fertility preservation, gender-affirming chest surgery, and legal gender marker changes.
Identified three distinct classes: Minimal Medical Intervention Pathway (43.14%), Mixed Medical Transition Pathway (33.17%), and Fertility Preservation Pathway (23.69%).
The Fertility Preservation Pathway was associated with younger initiation age and a transfeminine majority, while the Mixed Medical Transition Pathway had higher transmasculine representation, and the Minimal Medical Intervention Pathway had the highest proportion of nonbinary individuals.
No statistically significant differences were observed across the three transition pathways regarding psychiatric comorbidities.

Cite This Study

Maoz et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd49d6b95aff0620ec642 https://doi.org/10.1080/26895269.2026.2725892

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