Key result
Sugammadex 4 mg/kg added to aspirin did not reduce platelet aggregation compared to aspirin alone (ratio 1.01, lower 90% CI 0.91), meeting the pre-specified non-inferiority margin of 0.75.
Why the study?
Does the addition of sugammadex to aspirin reduce platelet aggregation in healthy adult males?
Population
26 healthy adult males
Comparison
Intravenous sugammadex 4 mg/kg combined with… vs Aspirin alone, sugammadex alone, and placebo alone
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
30 minutes post-dosing
Authors
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Reassures safe co-administration of sugammadex with aspirin; confirms no clinically relevant interaction on platelet aggregation in this RCT.
RCT (n=26)
Double-blind
randomized
Does the addition of sugammadex to aspirin reduce platelet aggregation in healthy adult males?
Effect estimate: Ratio 1.01 (95% CI lower limit of two-sided 90% CI 0.91)
Sugammadex 4 mg/kg does not have a clinically relevant interaction with aspirin on platelet aggregation or coagulation parameters in healthy males.
Kam et al. (2013) conducted an RCT in Healthy (n=26). Sugammadex and aspirin vs. Aspirin alone (i.v. placebo with once-daily oral aspirin 75 mg) was evaluated on Interaction between sugammadex and aspirin on platelet aggregation using collagen-induced whole-blood aggregometry (geometric mean ratio) (Ratio 1.01, 95% CI lower limit of two-sided 90% CI 0.91). Sugammadex 4 mg/kg added to aspirin did not reduce platelet aggregation compared to aspirin alone (ratio 1.01, lower 90% CI 0.91), meeting the pre-specified non-inferiority margin of 0.75.
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