Key result
Removal of extracellular potassium induces the Kv1.3 channel to transition to a non-conducting closed state which can switch into a non-conducting inactivated state upon depolarization.
Population
Mammalian Shaker-related voltage-gated K+ channels and mutant variants
Comparison
Removal of extracellular potassium and… vs Presence of extracellular potassium and…
Design
Preclinical
Authors
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Does not support changes in electrolyte management; leaves open Kv1.3's role in hypokalemia-related arrhythmias.
Removal of extracellular potassium induces mammalian Shaker-related K+ channels to enter a non-conducting closed state that can transition to an inactivated state upon depolarization.
Jäger et al. (1998) studied this question. Removal of extracellular potassium vs. Presence of extracellular potassium was evaluated on Channel state transitions and current amplitude. Removal of extracellular potassium induces the Kv1.3 channel to transition to a non-conducting closed state which can switch into a non-conducting inactivated state upon depolarization.
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