Key result
The truncated KcsA channel inactivated faster and to a greater degree than full-length KcsA, reflecting a rapid (1-2 µs) conductive-to-constricted transition of the selectivity filter.
Population
KcsA potassium channel (truncated form with C-terminal domain deleted and full-length)
Comparison
Molecular dynamics simulations and… vs Closed or partially open activation gate…
Design
Preclinical
Authors
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Advances molecular models of K+ channel gating; leaves open relevance to cardiac channelopathies.
The study provides mechanistic insights into C-type inactivation of potassium channels, demonstrating that it involves a rapid conductive-to-constricted transition of the selectivity filter allosterically controlled by the slow opening of the intracellular gate.
Li et al. (2018) studied KcsA potassium channel C-type inactivation. Truncated KcsA channel (C-terminal domain deleted) vs. Full-length KcsA channel was evaluated on C-type inactivation and selectivity filter constriction. The truncated KcsA channel inactivated faster and to a greater degree than full-length KcsA, reflecting a rapid (1-2 µs) conductive-to-constricted transition of the selectivity filter.
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