Key result
A decreased lymphocyte-to-monocyte ratio (OR 0.614), increased mean coronary diameter (OR 2.634), and elevated uric acid level (OR 1.006) were independent predictors of coronary slow flow in patients with isolated coronary artery ectasia.
Why the study?
The pathophysiology of isolated coronary artery ectasia with the coronary slow flow phenomenon is still unclear.
Observational (n=126)
No
In patients with isolated coronary artery ectasia, a lower lymphocyte-to-monocyte ratio, larger mean coronary diameter, and higher uric acid levels are independent predictors of the coronary slow flow phenomenon.
Answers are grounded in this paper and cite their sources.
Risk factors for CSF in isolated CAE identified; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: The pathophysiology of isolated coronary artery ectasia (CAE) with the coronary slow flow (CSF) phenomenon is still unclear. The purpose of this study was to investigate the risk factors for isolated CAE complicated with CSF. METHODS: A total of 126 patients with isolated CAE were selected retrospectively. The patients were grouped into the no CSF (NCSF) group (n = 55) and the CSF group (n = 71) according to the corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC). Data on demographics, laboratory measurements, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd), CTFC and diameters of three coronary arteries were collected. RESULTS: The proportions of males (84.5% vs. 61.8%, p = 0.004) and patients with a smoking history (63.4% vs. 43.6%, p = 0.021) were higher in the CSF group than in the NCSF group. The neutrophil-to-lymphocyte ratio (NLR) (2.08(1.68-3.21) vs. 1.89 ± 0.58, p = 0.001), mean diameter of coronary arteries (mean D) (5.50 ± 0.85 vs. 5.18 ± 0.91, p < 0.001), and uric acid (URIC) level (370.78 ± 109.79 vs. 329.15 ± 79.71, p = 0.019) were significantly higher in the CSF group, while the lymphocyte-to-monocyte ratio (LMR) (4.81 ± 1.66 vs. 5.96 ± 1.75, p < 0.001) and albumin (ALB) level (44.13 ± 4.10 vs. 45.69 ± 4.11, p = 0.036) were lower. Multivariable logistic analysis showed that the LMR (odds ratio: 0.614, 95% CI: 0.464-0.814, p = 0.001), mean D (odds ratio: 2.643, 95% CI: 1.54-4.51, p < 0.001) and URIC level (odds ratio: 1.006, 95% CI: 1.001-1.012, p = 0.018) were independent predictors of CSF in CAE. CONCLUSIONS: The LMR was a negative independent predictor of CSF in isolated CAE, while URIC level and mean D were positive independent predictors.
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Yang et al. (2021) conducted an observational in Isolated coronary artery ectasia with coronary slow flow (n=126). Lymphocyte-to-monocyte ratio (LMR) vs. No coronary slow flow was evaluated on Presence of coronary slow flow (OR 0.614, 95% CI 0.464-0.814, p=0.001). A decreased lymphocyte-to-monocyte ratio (OR 0.614), increased mean coronary diameter (OR 2.634), and elevated uric acid level (OR 1.006) were independent predictors of coronary slow flow in patients with isolated coronary artery ectasia.
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