Key result
Higher levels of CD34+ endothelial progenitor cells were independently associated with a lower likelihood of impaired left ventricular global circumferential strain (OR 0.64) in patients with type 2 diabetes.
Population
87 patients with type 2 diabetes mellitus and no history of coronary artery disease, mean age 62 ± 9 years…
Design
Cross-sectional
Authors
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CD34+ EPC depletion signals higher strain impairment risk in T2D; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=87)
No
Odds Ratio: 0.64 (95% CI 0.43–0.95)
p-value: p=0.03
In patients with type 2 diabetes without coronary artery disease, subclinical myocardial dysfunction assessed by echocardiographic strain is independently associated with depletion of CD34+ endothelial progenitor cells and increased oxidative stress.
Zhao et al. (2012) conducted a cross-sectional in Type 2 diabetes mellitus (n=87). CD34+ endothelial progenitor cells vs. Lower CD34+ EPC levels was evaluated on Impaired global circumferential strain (OR 0.64, 95% CI 0.43-0.95, p=0.03). Higher levels of CD34+ endothelial progenitor cells were independently associated with a lower likelihood of impaired left ventricular global circumferential strain (OR 0.64) in patients with type 2 diabetes.
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