Key result
Having a first-degree T2DM relative is linked to lower myocardial strain and elevated ET-1 despite normoglycemia.
Why the study?
First-degree relatives of individuals with T2DM are at increased cardiometabolic risk due to genetic predisposition, even without overt disease, but subclinical myocardial and endothelial dysfunction in this group required evaluation.
Do normoglycemic first-degree relatives of patients with type 2 diabetes mellitus exhibit subclinical myocardial dysfunction and elevated endothelial biomarkers compared to healthy controls?
Observational (n=151)
Do normoglycemic first-degree relatives of patients with type 2 diabetes mellitus exhibit subclinical myocardial dysfunction and elevated endothelial biomarkers compared to healthy controls?
Normoglycemic first-degree relatives of patients with type 2 diabetes exhibit early subclinical myocardial dysfunction and elevated ET-1 levels, indicating increased preclinical cardiovascular risk.
No immediate practice change for T2DM relatives; observational data leaves open whether strain or ET-1 predicts events.
BackgroundFirst-degree relatives (FDRs) of individuals with type 2 diabetes mellitus (T2DM) are at increased cardiometabolic risk due to genetic predisposition, even in the absence of overt disease. To evaluate subclinical myocardial dysfunction using speckle-tracking echocardiography (STE) and to assess serum levels of endothelial dysfunction related biomarkers, Endothelin-1 (ET-1), E-selectin, and Endocan, in normoglycemic FDRs of patients with T2DM, compared with healthy controls.MethodsThis study included 151 normoglycemic participants, comprising 75 individuals in the study group and 76 in the control group. Global longitudinal and circumferential strain values were assessed using STE. Serum levels of ET-1, E-selectin, and Endocan were measured using ELISA.ResultsET-1 levels were significantly higher in the study group (p = 0.047). STE revealed lower strain values in the study group in both SAX Basal/Mid/Apical (p = 0.027) and A4C/A2C/A3C mean views (p = 0.013). E-selectin showed a negative correlation with myocardial strain values, although no significant between-group difference was observed.ConclusionsNormoglycemic FDRs of T2DM patients exhibited subclinical myocardial strain abnormalities and elevated ET-1 levels, suggesting early cardiovascular alterations associated with genetic predisposition. ET-1 and E-selectin may serve as potential biomarkers for preclinical myocardial dysfunction in at-risk individuals.
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Culcuoglu et al. (2025) conducted an observational in Normoglycemic first-degree relatives of patients with type 2 diabetes mellitus (n=151). First-degree relative of T2DM patient vs. Healthy controls was evaluated on Myocardial strain values (A4C/A2C/A3C mean views) (p=0.013). Normoglycemic first-degree relatives of T2DM patients exhibited lower myocardial strain values (p=0.013) and elevated ET-1 levels (p=0.047) compared to healthy controls.
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