Key result
In asymptomatic patients with type 1 diabetes, subclinical systolic dysfunction was present in 39%, and visceral fat was a strong predictor of abnormal strain and increased coronary calcium score.
Why the study?
Patients with T1DM face increased cardiovascular disease risk and diabetic cardiomyopathy, but the occurrence of subclinical markers of cardiovascular risk and cardiac dysfunction in asymptomatic patients needed evaluation.
What is the prevalence of subclinical cardiac dysfunction and atherosclerosis in asymptomatic patients with type 1 diabetes mellitus?
Cross-Sectional (n=102)
What is the prevalence of subclinical cardiac dysfunction and atherosclerosis in asymptomatic patients with type 1 diabetes mellitus?
Subclinical left ventricular dysfunction and atherosclerosis are highly prevalent in asymptomatic T1DM patients, with visceral fat serving as a strong predictor of these abnormalities.
Subclinical dysfunction affects 39% of asymptomatic T1DM despite preserved LVEF; hypothesis-generating for visceral fat in risk stratification, needing prospective validation.
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Berendoncks et al. (2019) conducted a cross-sectional in Type 1 diabetes mellitus (T1DM) (n=102). Visceral fat was evaluated on Subclinical systolic dysfunction (global longitudinal peak systolic strain >-20%). In asymptomatic patients with type 1 diabetes, subclinical systolic dysfunction was present in 39%, and visceral fat was a strong predictor of abnormal strain and increased coronary calcium score.
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