Key result
A family history of hypertension in young normotensive subjects was associated with lower plasma BNP levels compared to those without a family history (23 vs 37 pg/ml, P<0.05), independent of gender.
Why the study?
Does a family history of hypertension alter autonomic control, diastolic function, and BNP levels in young normotensive subjects?
Population
87 age- and sex-matched young normotensive subjects with and without a family history of hypertension
Comparison
Family history of hypertension vs No family history of hypertension
Design
Cross-sectional
Authors
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Lower BNP in at-risk normotensives warrants no practice change; leaves open causal role in pre-hypertension.
Observational (n=87)
Does a family history of hypertension alter autonomic control, diastolic function, and BNP levels in young normotensive subjects?
Absolute Event Rate: 23% vs 37%
p-value: p=< 0.05
Young normotensive offspring of hypertensive families exhibit early alterations in autonomic control, diastolic function, and lower BNP levels, suggesting impaired BNP production may play a primary role in the pre-hypertensive state.
Pitzalis et al. (2001) conducted an observational in Normotension with family history of hypertension (n=87). Family history of hypertension vs. No family history of hypertension was evaluated on Plasma brain natriuretic peptide (BNP) levels (p=< 0.05). A family history of hypertension in young normotensive subjects was associated with lower plasma BNP levels compared to those without a family history (23 vs 37 pg/ml, P<0.05), independent of gender.
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