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Since the start of the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we have sought to understand the predictors of severe COVID-19 and mortality. Data show that age and chronic comorbidities are major risk factors, but what about immunosuppression? Patients with malignant disease and recipients of solid-organ transplants might be at increased risk, but evidence is less clear for people with other types of immunocompromise, including HIV.1 Are people with HIV, even those with well controlled viraemia and immune reconstitution, at risk of more severe COVID-19 and death or is the risk associated with overlapping demographic and comorbidity characteristics?
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Waters et al. (2020) studied this question.
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