Key result
1-hour plasma glucose concentration showed a fair agreement with 2-hour plasma glucose concentration (Cohen's Kappa 0.405, p < 0.001) for diagnosing pre-diabetes in patients with morbid obesity.
Why the study?
One-hour plasma glucose during an OGTT may be an alternative to two-hour plasma glucose to identify individuals at increased risk of hyperglycaemia, but its role is not fully understood.
Does 1-hour plasma glucose testing agree with 2-hour plasma glucose testing for diagnosing pre-diabetes in patients with morbid obesity?
Observational (n=656)
No
Does 1-hour plasma glucose testing agree with 2-hour plasma glucose testing for diagnosing pre-diabetes in patients with morbid obesity?
Effect estimate: Cohen's Kappa 0.405
p-value: p=<0.001
1-hour plasma glucose testing shows fair agreement with 2-hour testing for pre-diabetes diagnosis and may be a useful indicator of β-cell dysfunction and insulin resistance in patients with morbid obesity.
1hPG may detect additional high-risk individuals missed by standard criteria; leaves open whether it improves cardiometabolic risk prediction or warrants routine use.
BACKGROUND: One hour plasma glucose concentration (1hPG) during an oral glucose tolerance test (OGTT) may be an alternative to 2-h plasma glucose concentration (2hPG) in the identification of individuals at increased risk of hyperglycaemia, although its role is not fully understood. AIM: We aim to investigate the relationship of these measures with other glucose parameters, as well as their relationship with cardiometabolic risk markers and the level of agreement for prediabetes mellitus diagnosis, in a sample of patients with morbid obesity. METHODS: We retrospectively evaluated 656 patients with morbid obesity without diagnosed diabetes. To define prediabetes with 2hPG, 2022 American Diabetes Association guidelines criteria were used, while for 1hPG, glucose ≥ 155 mg/dL was considered. Cohen's Kappa coefficient was used to assess the agreement between both measures of prediabetes mellitus diagnosis. RESULTS: A Cohen's Kappa coefficient of 0.405 (p < 0.001) was obtained. The 1hPG were positively correlated with homeostatic model assessment for insulin resistance (HOMA-IR) (ρ = 0.281, p < 0.001), fasting plasma glucose (FPG) (ρ = 0.581, p < 0.001), glycated haemoglobin (Hb1AC) (ρ = 0.347, p < 0.001) and were negatively correlated with homeostatic model assessment for cell-β function (HOMA-β) (ρ = -0.092, p = 0.018). 2hPG were also correlated with the same parameters, except for HOMA-β. CONCLUSION: A fair agreement between 1 and 2hPG was verified. 1hPG criteria may be a useful indicator of β-cell dysfunction and insulin resistance in patients with morbid obesity without diabetes diagnosis.
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Guerreiro et al. (2022) conducted an observational in Morbid obesity without diagnosed diabetes (n=656). 1-hour plasma glucose concentration (1hPG) during OGTT vs. 2-hour plasma glucose concentration (2hPG) during OGTT was evaluated on Agreement between 1hPG and 2hPG for pre-diabetes diagnosis (Cohen's Kappa 0.405, p=<0.001). 1-hour plasma glucose concentration showed a fair agreement with 2-hour plasma glucose concentration (Cohen's Kappa 0.405, p < 0.001) for diagnosing pre-diabetes in patients with morbid obesity.
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