Key result
Grade 2 or 3 adrenal cortical carcinoma was associated with a significantly shorter median survival compared to Grade 1 tumors (4.3 vs 24.3 months; P<0.05).
Population
91 autopsy cases of patients with adrenal cortical carcinoma, including 52 men and 39 women with a mean age…
Comparison
Histological grading and immunohistochemical… vs Adrenal cortical adenoma for immunohistochemical…
Design
Cohort
Authors
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Supports histological grading for prognosis in adrenal cortical carcinoma; hypothesis-generating and requires prospective validation before influencing decisions.
Observational (n=91)
Absolute Event Rate: 4.3% vs 24.3%
p-value: p=<0.05
Histological grading of adrenal cortical carcinoma strongly correlates with survival, and vimentin staining helps differentiate it from adenomas.
Masato Nakano (1988) conducted an observational in Adrenal cortical carcinoma (n=91). Grade 2 or 3 tumor grading vs. Grade 1 tumor grading was evaluated on Median survival (p=<0.05). Grade 2 or 3 adrenal cortical carcinoma was associated with a significantly shorter median survival compared to Grade 1 tumors (4.3 vs 24.3 months; P<0.05).
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