Key result
In four elderly patients with diffuse alveolar hemorrhage associated with uncontrolled warfarin use, clinical and radiological findings rapidly improved after warfarin discontinuation.
Case Report (n=4)
No
Uncontrolled warfarin use in elderly patients can lead to diffuse alveolar hemorrhage, a rare but life-threatening complication that resolves upon drug discontinuation and supportive care.
Case reports link uncontrolled warfarin to DAH in elderly patients; leaves open need for incidence studies and monitoring trials.
Diffuse alveolar hemorrhage (DAH) caused by immune and non-immune etiological factors, characterized by diffuse alveolar consolidation often presents with the clinical triad of dyspnea, hemoptysis, anemia, as a result of the distruption of the alveolocapillary membrane of the lung. We aimed to present above 65 yaears 4 cases followed in our clinic with diffuse alveolar hemorrhage as a rare complication of uncontrolled use of anticoagulant (warfarin) therapy. The cases was diagnosed as diffuse alveoler hemorrahage based on clinical, radiological and bronghoscopic data. After warfarin treatment was withdrawn, clinical and radiological signs recovered rapidly and the existent situation was thought to be DAH related with warfarin use after excluding other reasons. We think that the current cases is a rare disease of warfarin therapy leading to DAH.
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Kurt et al. (2015) conducted a case report in Diffuse alveolar hemorrhage (n=4). Warfarin was evaluated on Clinical and radiological recovery. In four elderly patients with diffuse alveolar hemorrhage associated with uncontrolled warfarin use, clinical and radiological findings rapidly improved after warfarin discontinuation.
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