Key result
Multimodality therapy including surgery, radiotherapy, and chemotherapy successfully controlled primary pulmonary synovial sarcoma with brain metastasis, leading to prolonged survival.
Case Report (n=1)
No
A multidisciplinary approach including surgery, radiation, and chemotherapy may be useful for managing highly aggressive primary pulmonary synovial sarcoma with brain metastasis.
Multimodal resection, radiation, and chemotherapy feasible in this rare sarcoma; leaves open standardized protocols pending larger series.
A 54-year-old man was referred to our hospital due to a mass shadow noted on a chest X-ray. Thoracoscopic lobectomy yielded a diagnosis of primary pulmonary synovial sarcoma according to the histology and SYT-SSX1 gene analyses. Five months after the thoracic surgery, he developed brain metastasis; therefore, we performed resection of the brain metastatic focus followed by radiotherapy. As a local recurrence in the thoracic cavity concurrently emerged, systemic chemotherapy was also administered. These observations indicated that a multidisciplinary approach may be useful against primary pulmonary synovial sarcoma, although there is presently no established therapeutic strategy due to its rarity and highly aggressive nature.
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Ogino et al. (2016) conducted a case report in Primary pulmonary synovial sarcoma (n=1). Multimodality therapy (surgery, radiotherapy, and chemotherapy) was evaluated on Clinical response and survival. Multimodality therapy including surgery, radiotherapy, and chemotherapy successfully controlled primary pulmonary synovial sarcoma with brain metastasis, leading to prolonged survival.
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