Key result
Heparin combined with chemotherapy was proposed to prevent fibrin deposition and promote healing of valvular vegetations in subacute bacterial endocarditis, though specific results are not reported.
Early historical rationale for combining heparin with sulfonamides to treat subacute bacterial endocarditis by preventing fibrin deposition on valvular vegetations.
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Early proposal for heparin adjunct in endocarditis warrants no practice change; leaves open modern trials of anticoagulation.
Louis N. Katz (1944) studied Subacute bacterial endocarditis. Heparin and chemotherapy was evaluated. Heparin combined with chemotherapy was proposed to prevent fibrin deposition and promote healing of valvular vegetations in subacute bacterial endocarditis, though specific results are not reported.
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