Key result
Treadmill training induced bradycardia at submaximal exercise in rats of the same magnitude regardless of concurrent treatment with metoprolol or propranolol compared to trained untreated controls.
Why the study?
Does beta receptor blockade prevent training-induced bradycardia in rats?
Population
40 Sprague-Dawley rats
Comparison
12 weeks of treadmill training with oral… vs Sedentary controls and trained untreated rats
Design
Preclinical
Follow-up
12 weeks
Authors
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Beta blockade does not prevent training-induced bradycardia in rats; leaves open mechanisms and human relevance.
Does beta receptor blockade prevent training-induced bradycardia in rats?
Stimulation of cardiac beta receptors or heart rate increase during exercise are not critical for the development of training-induced bradycardia in rats.
Eva Nylander (1985) studied this question. Metoprolol or propranolol during treadmill training vs. Trained untreated rats and sedentary controls was evaluated on Training-induced bradycardia at submaximal exercise. Treadmill training induced bradycardia at submaximal exercise in rats of the same magnitude regardless of concurrent treatment with metoprolol or propranolol compared to trained untreated controls.
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