Key result
Quinacrine blocked L-type Ca2+ channels in guinea pig smooth muscle myocytes with an IC50 of 1.1-1.3 microM, approximately five times more potent than in cardiac ventricular myocytes (IC50 5.6 microM).
Quinacrine acts as a direct, potent blocker of L-type Ca2+ channels from the outside of the cell membrane, with approximately five times greater potency in smooth muscle compared to cardiac myocytes.
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Quinacrine may offer vascular-selective Ca2+ blockade; leaves open clinical translation pending human studies.
Nagano et al. (1996) studied this question. Quinacrine was evaluated on IC50 for voltage-dependent Ca2+ channel current (ICa) block. Quinacrine blocked L-type Ca2+ channels in guinea pig smooth muscle myocytes with an IC50 of 1.1-1.3 microM, approximately five times more potent than in cardiac ventricular myocytes (IC50 5.6 microM).
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