Key result
Quinacrine causes a slow, voltage-dependent block of open end-plate channels, with a binding rate constant estimated at 10(8) M-1 s-1.
Population
Voltage-clamped frog end-plates
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for quinacrine effects on neuromuscular transmission in mammals.
Quinacrine induces a slow, voltage-dependent block of open end-plate channels, with kinetics that depend on agonist concentration.
Adams et al. (1980) studied this question. Quinacrine was evaluated on Relaxation of agonist-induced currents in response to a voltage step. Quinacrine causes a slow, voltage-dependent block of open end-plate channels, with a binding rate constant estimated at 10(8) M-1 s-1.