Key result
Children with ventricular septal defect had a significantly lower mean left ventricular mass compared to controls (75.8 vs 113.5; P=0.022), with no difference in ejection fraction.
Why the study?
Assessment of left ventricular longitudinal systolic dynamics represents a major milestone in evaluating systolic function in children with ventricular septal defect.
Do children with VSD have different left ventricular function, left ventricular mass, and descending aorta blood flow compared to age and sex-matched controls?
Case-Control (n=170)
Do children with VSD have different left ventricular function, left ventricular mass, and descending aorta blood flow compared to age and sex-matched controls?
Children with VSD have lower left ventricular mass compared to matched controls, but similar left ventricular ejection fraction and descending aorta blood flow.
Answers are grounded in this paper and cite their sources.
Reduced LVM in pediatric VSD may reflect altered hemodynamics; leaves open validation for systolic function assessment.
BACKGROUND: The assessments of left ventricular (LV) longitudinal systolic dynamics in children with ventricular septal defect (VSD) have achieved a major milestone in the evaluation of LV systolic function. OBJECTIVES: This study aims to evaluate the LV function, LV mass (LVM), and the descending aorta blood flow in children with VSD compared to that obtained in age and sex-matched controls. RESULTS: The mean LVM of the control, 113.5 ± 123.9 was higher than that of those who had VSD, 75.8 ± 83.9, and the difference in mean was found to be statistically significant (Mann-Whitney U = 2.322, P = 0.022). The mean EF of the control, 67.9 ± 10.3 was comparable to that of those with VSD, 65.6 ± 13.9, (Student's t = 1.223, P = 0.223). Similarly, the mean descending aorta blood flow of control, 1.6 ± 2.2 was comparable to that of those with VSD, 3.9 ± 16.1, (Mann-Whitney U = 1.002, P = 0.321). There was a very weak positive correlation between LVM and descending aorta blood flow among the subjects (n = 85, r = 0.117, P = 0.425). There was a very weak negative correlation between LVM and descending aorta blood flow among control. (n = 85, r = -0.065, P = 0.609). CONCLUSION: The LVM among children with VSD is lower than controls but there is no difference between LV function in subjects and controls. There is a linear increase of LVM with descending aorta blood flow.
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Chinawa et al. (2024) conducted a case-control in Ventricular septal defect (n=170). Ventricular septal defect vs. Age and sex-matched controls was evaluated on Left ventricular mass (p=0.022). Children with ventricular septal defect had a significantly lower mean left ventricular mass compared to controls (75.8 vs 113.5; P=0.022), with no difference in ejection fraction.
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