Trends in isolated aortic valve replacement in middle‑aged patients over the last 10 years: epidemiology, risk factors, valve pathology, valve types, and outcomes
Key result
In middle-aged patients undergoing aortic valve replacement, in-hospital mortality did not differ significantly between biological and mechanical valves (3.69% vs 3.33%; P=0.85).
Why the study?
Valve prosthesis selection in aortic valve replacement is particularly difficult in middle-aged patients aged 60 to 70 years.
Does the choice of biological versus mechanical valve affect in-hospital mortality in middle-aged patients undergoing isolated aortic valve replacement?
Population
4912 consecutive adult patients undergoing isolated aortic valve surgery, including 1531 middle-aged patients
Comparison
Mechanical valves vs biological valves over time
Design
Single-center registry-based retrospective cohort study
Authors
Discussion
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Member takes
Implication
Shift to bioprostheses in middle-aged AVR patients observed with stable mortality; leaves open optimal prosthesis selection pending long-term outcomes.
Study Design
Type
Cohort (n=4,912)
Multicenter
No
Structured PICO
Does the choice of biological versus mechanical valve affect in-hospital mortality in middle-aged patients undergoing isolated aortic valve replacement?
P
Population
4,912 consecutive adult patients undergoing isolated aortic valve surgery between 2006 and 2016, with a focus on 1,531 middle-aged patients (60-70 years old).
E
Exposure
Aortic valve replacement with biological valves
C
Comparator
Aortic valve replacement with mechanical valves
O
Outcome
Changes in the number of procedures, characteristics, surgical details, and in-hospital mortalityhard clinical
Main Result
Absolute Event Rate: 3.69% vs 3.33%
p-value: p=0.85
There has been a rapid shift from mechanical to biological valves for isolated aortic valve replacement in middle-aged patients over the last decade, with comparable in-hospital mortality.
Cite This Study
Filip et al. (2019) conducted a cohort in Isolated aortic valve replacement (n=4,912). Biological valves vs. Mechanical valves was evaluated on In-hospital mortality (p=0.85). In middle-aged patients undergoing aortic valve replacement, in-hospital mortality did not differ significantly between biological and mechanical valves (3.69% vs 3.33%; P=0.85).