Key result
The MYH9 rs3752462 CC genotype was associated with a significantly lower risk of high systolic blood pressure in patients with chronic kidney disease compared to the TT genotype (OR 0.24; P=0.002).
Why the study?
Are MYH9 gene polymorphisms associated with hypertension in Chinese patients with chronic kidney disease?
Case-Control (n=594)
Are MYH9 gene polymorphisms associated with hypertension in Chinese patients with chronic kidney disease?
Odds Ratio: 0.24
Absolute Event Rate: 4.3% vs 17.1%
p-value: p=0.002
The rs3752462 polymorphism of the MYH9 gene is associated with an elevated risk for high systolic blood pressure in Chinese patients with chronic kidney disease.
MYH9 rs3752462 T allele associates with higher SBP risk in Chinese CKD; leaves open whether genotyping informs management.
BACKGROUND/AIMS: This study explored the correlation between hypertension and non-muscle myosin heavy chain 9 (MYH9) gene polymorphisms in Chinese chronic kidney disease (CKD) patients. METHODS: This case-control study included 301 patients with CKD and 293 healthy controls. The E1 haplotype single nucleotide polymorphisms (SNPs) rs3752462 and rs4821480 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The association between MYH9 polymorphisms and high systolic blood pressure (SBP ≥ 140 mmHg) susceptibility in CKD patients was analysed. RESULTS: The cases and controls had similar genotype and allele distributions at rs3752462 and rs4821480. No GG genotype at rs4821480 was observed. Patients with SBP < 140 mmHg were more likely to have the CC genotype (17.1%) than patients with SBP ≥ 140 mmHg (4.3%) (P = 0.001). Creatinine clearance (OR = 0.99, 95% CI = 0.98-0.10, P = 0.01) was associated with SBP in patients with CKD. The risk of SBP ≥ 140 mmHg was 0.24-fold greater among patients with the CC genotype than among patients with the TT genotype (P = 0.002). CONCLUSION: The rs3752462 polymorphism of MYH9 is associated with SBP in patients with CKD. The T allele in the dominant model was associated with an elevated risk for high SBP.
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Liu et al. (2016) conducted a case-control in Chronic kidney disease and hypertension (n=594). MYH9 rs3752462 and rs4821480 polymorphisms vs. TT genotype / Healthy controls was evaluated on High systolic blood pressure (SBP ≥ 140 mmHg) (OR 0.24, p=0.002). The MYH9 rs3752462 CC genotype was associated with a significantly lower risk of high systolic blood pressure in patients with chronic kidney disease compared to the TT genotype (OR 0.24; P=0.002).
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