Key result
Visceral adipose tissue in children showed a significant inflammatory gene profile compared to subcutaneous tissue, including a 30-fold increase in haptoglobin and 7-fold increase in IL-10 (P<0.001).
Why the study?
Are there differences in inflammatory gene expression profiles between visceral and subcutaneous adipose tissue in children?
Cross-Sectional (n=71)
Are there differences in inflammatory gene expression profiles between visceral and subcutaneous adipose tissue in children?
Visceral adipose tissue in children exhibits an early inflammatory gene profile compared to subcutaneous tissue, which may contribute to future metabolic and cardiovascular risk.
Visceral adipose inflammation may emerge early in children; hypothesis-generating for its contribution to future cardiometabolic risk.
The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n = 71, [54 boys], 6.0 ± 4.3 years). Affymetrix microarrays (n = 20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30-fold increase in haptoglobin (P = 0.005), 7-fold increase in IL-10 (P < 0.001), 8-fold decrease in VEGF (P = 0.01) and a 28-fold decrease in TBOX15 (P < 0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.
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Tam et al. (2011) conducted a cross-sectional in Children having elective surgery (n=71). Visceral adipose tissue vs. Subcutaneous adipose tissue was evaluated on Gene expression profile (30-fold increase in haptoglobin, 7-fold increase in IL-10, p=<0.001). Visceral adipose tissue in children showed a significant inflammatory gene profile compared to subcutaneous tissue, including a 30-fold increase in haptoglobin and 7-fold increase in IL-10 (P<0.001).
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