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Prolylproline has been synthesized by both classical peptide synthesis method utilizing tert -butoxycarbonyl or trifluoroacetyl protection of the NH group and carbodiimide-promoted peptide bond formation and by opening of the dioxopiperazine ring in octahydrodipyrrolo[1,2- a :1′,2′- d ]pyrazine-5,10-dione obtained by thermolysis of proline methyl ester.
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Гайдукевич et al. (2019) studied this question.
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