Key result
Renal sympathetic denervation is an effective and safe approach for resistant hypertension, resulting in significant reductions in systolic and diastolic blood pressure.
Why the study?
Does percutaneous renal sympathetic denervation reduce blood pressure in patients with resistant hypertension?
Does percutaneous renal sympathetic denervation reduce blood pressure in patients with resistant hypertension?
Renal sympathetic denervation is presented as an effective and safe percutaneous approach for managing resistant hypertension.
May support renal denervation in resistant hypertension; leaves open need for confirmatory RCTs before practice change.
The authors review the concept of resistant hypertension and the involvement of the sympathetic nervous system in hypertension as a rational basis for the technique of renal sympathetic denervation (RSD) performed percutaneously. This revision is the result of an active search for scientific articles with the term "renal denervation" in the Medline and PubMed databases. The techniques and devices used in the procedure are presented, as well as clinical outcomes at six, 12 and 24 months after the intervention with the Symplicity catheter. Significant decreases and progressively higher reductions of systolic and diastolic blood pressure were observed after RSD. The complication rate was minimal. New devices for RSD and its ongoing clinical studies are cited. In conclusion, the RSD presents itself as an effective and safe approach to resistant hypertension. Results from ongoing studies and longer follow-up of these patients are expected to confirm the initial results and put into perspective the expansion of the procedure use in hypertension approach.
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Brandão et al. (2013) conducted a review in Resistant hypertension. Renal sympathetic denervation was evaluated on Systolic and diastolic blood pressure. Renal sympathetic denervation is an effective and safe approach for resistant hypertension, resulting in significant reductions in systolic and diastolic blood pressure.
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