Self-organized environment-sensitive inulin–doxorubicin conjugate with a selective cytotoxic effect towards cancer cells

An inulin-based copolymer bearing high dose doxorubicin (18.45 % w/w), INU-EDA-P,C-DOXO, was prepared by coupling doxorubicin with inulin though citraconylamide bridge used as pH sensitive spacer. Its smart and selective anticancer effect was proved.