January 1, 1976Hospital Practice
CPK Isoenzymes in Evaluation of Myocardial Ischemic Injury
Key result
The MB isoenzyme of creatine phosphokinase provides a specific plasma assay for diagnosing myocardial infarction and measuring the extent of myocardial damage.
Design
Review
Authors
Discussion
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Member takes
Implication
May support specific MI diagnosis and damage quantification with CK-MB; leaves open validation against modern troponin assays.
Structured PICO
E
Exposure
Measurement of MB isoenzyme of creatine phosphokinase (CPK-MB)
O
Outcome
Diagnosis and measurement of the extent of myocardial damagesurrogate
The MB isoenzyme of creatine phosphokinase provides a specific biomarker for diagnosing and quantifying myocardial infarction, overcoming the lack of specificity of previous enzymatic criteria.
Cite This Study
Roberts et al. (1976) conducted a review in Myocardial infarction. MB isoenzyme of creatine phosphokinase (CPK-MB) assay was evaluated. The MB isoenzyme of creatine phosphokinase provides a specific plasma assay for diagnosing myocardial infarction and measuring the extent of myocardial damage.