Key result
Flow-mediated vasodilatation measurement using a semi-automatic device demonstrated acceptable reliability across institutions, with an inadequate scan rate of approximately 10% in Japanese subjects.
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FMD measurement using a semi-automatic device has acceptable reliability and can be categorized as a clinically applicable tool with established reference values for Japanese subjects.
The FMDJ study, a multicenter prospective observational study conducted in Japan, demonstrated the acceptable reliability of measurement of flow-mediated vasodilatation (FMD) using a semi-automatic device in individual institutions. However, in about 10% of Japanese subjects, adequate scans to determine the brachial arterial diameter failed to be obtained. The prevalence of inadequate scans was higher in women than in men, while obesity had no influence on the inadequate scan rate. The FMDJ study also proposed that attending periodic refresher courses on the measurement of FMD is needed for maintaining competency. Finally, the FMDJ study proposed reference values for FMD. Thus, FMD measurement may be categorized as a clinically applicable tool on the basis of class IIb (exploratory cohort study with good reference standards) evidence.
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Tomiyama et al. (2017) conducted a review in Endothelial dysfunction (n=8,363). Flow-mediated vasodilatation (FMD) measurement was evaluated on Reliability and inadequate scan rate of FMD measurement. Flow-mediated vasodilatation measurement using a semi-automatic device demonstrated acceptable reliability across institutions, with an inadequate scan rate of approximately 10% in Japanese subjects.
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