August 30, 2017Journal of Hypertension
Office, standardized and 24-h ambulatory blood pressure and renal function loss in renal transplant patients
Key result
Baseline 24-h ambulatory blood pressure predicted a combined renal endpoint of GFR loss >30%, end-stage kidney disease, or death (HR 1.11; 95% CI 1.03-1.19 per 5 mmHg increase) over 3.7 years.
Why the study?
Does ambulatory blood pressure monitoring predict renal function loss in renal transplant patients?
Population
260 renal transplant patients
Design
Cohort
Follow-up
3.7 years
Authors
Discussion
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Member takes
Implication
May aid risk stratification in renal transplant recipients; supports ABPM-renal outcome link but leaves open whether lowering BP improves endpoints.
Study Design
Type
Cohort (n=260)
Structured PICO
Does ambulatory blood pressure monitoring predict renal function loss in renal transplant patients?
P
Population
260 renal transplant patients followed for 3.7 years to evaluate the relationship between ambulatory blood pressure and renal function loss.
E
Exposure
Baseline 24-h ambulatory blood pressure monitoring (ABPM) and repeated office BP measurements
O
Outcome
Combined renal end point (GFR loss >30%, end-stage kidney disease or death) over a 3.7 years follow-upcomposite
Main Result
Hazard Ratio: 1.11 (95% CI 1.03–1.19)
In renal transplant patients, night-time systolic blood pressure is a strong predictor of the risk of renal function loss over time.
Cite This Study
Mallamaci et al. (2017) conducted a cohort in Renal transplant (n=260). 24-h ambulatory blood pressure (per 5 mmHg increase) was evaluated on Combined renal end point (GFR loss >30%, end-stage kidney disease or death) (HR 1.11, 95% CI 1.03-1.19). Baseline 24-h ambulatory blood pressure predicted a combined renal endpoint of GFR loss >30%, end-stage kidney disease, or death (HR 1.11; 95% CI 1.03-1.19 per 5 mmHg increase) over 3.7 years.