Key result
Cyclic mechanical strain induced a differentiated, contractile phenotype in vascular smooth muscle cells in a frequency-dependent manner, mediated at least partly by the p38 pathway.
Population
Vascular smooth muscle cells (VSMCs)
Comparison
Cyclic mechanical strain of 10% elongation at… vs 0 Hz (no strain)
Design
Preclinical
Follow-up
24 hours
Authors
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Supports p38-mediated VSMC differentiation by cyclic strain; hypothesis-generating for vascular mechanobiology with no immediate clinical implications.
Cyclic mechanical strain modulates vascular smooth muscle cell phenotype in a frequency-dependent manner, mediated at least partly by the p38 MAPK pathway.
Qu et al. (2007) studied this question. Cyclic mechanical strain vs. 0 Hz (static) was evaluated on VSMC phenotype (cell morphology, cell area, protein and mRNA expression of differentiation markers). Cyclic mechanical strain induced a differentiated, contractile phenotype in vascular smooth muscle cells in a frequency-dependent manner, mediated at least partly by the p38 pathway.
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