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January 1, 2020Journal of Blood MedicineOpen Access

Platelet Count and Bleeding in Patients Receiving Anticoagulant Therapy for Venous Thromboembolism: Lesson from the RIETE Registry

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Key result

The abstract reports clinical experience from the RIETE registry concerning the relationship between different platelet values and bleeding risk in VTE patients on anticoagulants, without providing quantitative results.

Why the study?

Major bleeding is a dangerous complication of anticoagulant treatment for VTE, and risk scores commonly consider platelet count, particularly thrombocytopenia.

Does platelet count affect the risk of bleeding in patients receiving anticoagulant therapy for venous thromboembolism?

Population

Patients receiving anticoagulant treatment for VTE in the RIETE registry

Comparison

Different values of platelets

Design

Registry-based study

Authors

PMPierpaolo Di MiccoMMManuel Monréal

Discussion

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Member takes

Overview

Should not yet guide platelet-based anticoagulation adjustments in VTE; hypothesis-generating observational data needing prospective validation.

Study Design

Type

Observational

Structured PICO

Does platelet count affect the risk of bleeding in patients receiving anticoagulant therapy for venous thromboembolism?

P
Population
Patients from the RIETE registry receiving anticoagulant therapy for venous thromboembolism.
E
Exposure
Anticoagulant treatment in the presence of different values of platelets
O
Outcome
Risk of bleeding (major bleeding)safety

This paper reports clinical experience from the RIETE registry regarding the relationship between platelet count and bleeding risk in VTE patients on anticoagulation, though specific results are not provided in the abstract.

Cite This Study

Micco et al. (2020) conducted an observational in Venous Thromboembolism (VTE). Different values of platelets was evaluated on Risk of bleeding. The abstract reports clinical experience from the RIETE registry concerning the relationship between different platelet values and bleeding risk in VTE patients on anticoagulants, without providing quantitative results.

synapsesocial.com/papers/6a9c324342df18bb42c53db4https://doi.org/10.2147/jbm.s234053
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Validation of a score for predicting fatal bleeding in patients receiving anticoagulation for venous thromboembolism2013 · 51 citations
  2. 2Platelet Count and Major Bleeding in Patients Receiving Vitamin K Antagonists for Acute Venous Thromboembolism, Findings From Real World Clinical Practice2015 · 9 citations
  3. 3Hospital volume and outcomes for acute pulmonary embolism: multinational population based cohort study2019 · 73 citations
  4. 4Net Clinical Benefit of Non-vitamin K Antagonist Oral Anticoagulants for Venous Thromboembolism Prophylaxis in Patients With Cancer: A Systematic Review and Trade-Off Analysis From 9 Randomized Controlled Trials2018 · 16 citations
  5. 5Safety, effectiveness, and health care cost comparisons among elderly patients with venous thromboembolism prescribed warfarin or apixaban in the United States Medicare population2019 · 14 citations