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November 19, 2021NutrientsOpen Access

Mokko Lactone Attenuates Doxorubicin-Induced Hepatotoxicity in Rats: Emphasis on Sirt-1/FOXO1/NF-κB Axis

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Key result

Mokko lactone prevented doxorubicin-induced liver injury in rats by ameliorating transaminase elevations and oxidative stress, partially through the Sirt-1/FOXO1/NF-κB axis.

Why the study?

Doxorubicin causes serious adverse effects including hepatotoxicity, prompting evaluation of the potential protective effects of mokko lactone against doxorubicin-induced hepatotoxicity in rats.

Does Mokko lactone prevent doxorubicin-induced hepatotoxicity in rats?

Population

Rats

Comparison

Mokko lactone against doxorubicin-induced hepatotoxicity

Authors

ASAlaa SirwiKing Abdulaziz UniversityRSRasheed A. ShaikKing Abdulaziz UniversityAAAbdulmohsin J. AlamoudiKing Abdulaziz University

Discussion

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Member takes

Overview

Not ready for clinical use; leaves open translation of rat hepatoprotection to doxorubicin-treated patients.

Structured PICO

Does Mokko lactone prevent doxorubicin-induced hepatotoxicity in rats?

P
Population
Rats evaluated for the protective effects of Mokko lactone against doxorubicin-induced hepatotoxicity.
I
Intervention
Mokko lactone (ML)
C
Comparator
Doxorubicin alone
O
Outcome
Hepatotoxicity (serum activities of alanine transaminase, aspartate transaminase, and alkaline phosphatase; liver architecture)surrogate

Mokko lactone demonstrates protective effects against doxorubicin-induced hepatotoxicity in a rat model, likely mediated through the Sirt-1/FOXO1/NF-κB axis.

Cite This Study

Sirwi et al. (2021) studied Doxorubicin-induced hepatotoxicity. Mokko lactone vs. Doxorubicin was evaluated on Hepatotoxicity (serum ALT, AST, ALP and liver histology). Mokko lactone prevented doxorubicin-induced liver injury in rats by ameliorating transaminase elevations and oxidative stress, partially through the Sirt-1/FOXO1/NF-κB axis.

synapsesocial.com/papers/6a9c341d42df18bb42c53e02https://doi.org/10.3390/nu13114142
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