Key result
Increased cIMT correlates with lower LVEF in Type 2 diabetes with preclinical heart failure.
Why the study?
Type 2 diabetes mellitus is a common risk factor for cardiovascular disease that increases heart failure risk, but correlations between subclinical cardiovascular disease features and echocardiographic morpho-functional parameters needed evaluation.
Cross-Sectional (n=255)
In adults with T2DM and preclinical stage A/B heart failure, subclinical vascular disease markers such as cfPWV and cIMT correlate significantly with adverse cardiac morpho-functional parameters.
Answers are grounded in this paper and cite their sources.
Association in T2DM with preclinical HF is hypothesis-generating; leaves open whether vascular markers predict HF progression or warrant intervention.
Purpose: Type 2 diabetes mellitus (T2DM) is a common risk factor for cardiovascular disease which increases the risk of heart failure. This study aimed to determine whether clinical characteristics and subclinical cardiovascular disease (CVD) features are correlated with echocardiographic morpho-functional parameters of T2DM patients. Patients and Methods: Two hundred and fifty-five T2DM patients without a history of coronary heart disease were enrolled in this cross-sectional study. The demographic characteristics, glucose and lipid levels were assessed for each patient. Carotid ultrasonography and peripheral artery examination were performed to measure carotid intima-media thickness (cIMT), carotid plaque, ankle-brachial index (ABI), brachial artery pulse wave velocity (baPWV), and carotid-femoral pulse wave velocity (cfPWV). Furthermore, echocardiography was conducted to evaluate cardiac morphology and systolic and diastolic function. The relationship between clinical characteristics, subclinical cardiovascular diseases, and cardiac morpho-functional parameters was explored with the Pearson and stepwise multivariable linear regression analyses. Results: A total of 255 subjects aged 18-80 years were enrolled in the study. Multiple regression analysis revealed that left ventricular mass index (LVMI) was correlated with age (β=0.463, p = 0.000) and systolic blood pressure (SBP) (β=0.179, p = 0.003). Relative wall thickness (RWT) was related to cfPWV (β=0.006, p = 0.007) and homeostasis model assessment of insulin resistance (HOMA-IR) (β=0.000, p = 0.036). In contrast, left ventricular ejection fraction (LVEF) was inversely related to cIMT (β=-0.925, p = 0.019). The ratio of the peak flow velocity of early diastole to atrial contraction (peak E/A) was correlated with age (β=-0.014, p = 0.000), diastolic blood pressure (DBP) (β=-0.006, p = 0.001) and cfPWV (β=-0.025, p = 0.044). Conclusion: In preclinical stage A/B heart failure adults with T2DM, age, BP, HOMA-IR, cfPWV and cIMT are correlated with cardiac morpho-functional parameters.
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Xiao et al. (2022) conducted a cross-sectional in Preclinical stage A/B heart failure with Type 2 Diabetes (n=255). Subclinical cardiovascular disease features and clinical characteristics was evaluated on Correlation with cardiac morpho-functional parameters (LVMI, RWT, LVEF, peak E/A). In adults with Type 2 diabetes and preclinical heart failure, subclinical cardiovascular features correlated with cardiac parameters, including an inverse relationship between LVEF and cIMT.
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