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July 6, 2013BMC Evolutionary BiologyOpen Access

Evolution of the myosin heavy chain gene MYH14 and its intronic microRNA miR-499: muscle-specific miR-499 expression persists in the absence of the ancestral host gene

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Key result

Medaka miR-499 is expressed in a muscle-specific manner despite the complete evolutionary loss of its ancestral host gene MYH14, indicating the conversion of an intronic to a non-intronic miRNA.

Authors

SBSharmin Siddique BhuiyanDr. Bhim Rao Ambedkar UniversitySKShigeharu KinoshitaThe University of TokyoCWChaninya WongwarangkanaChulalongkorn University

Discussion

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Implication

No immediate clinical implications for cardiac muscle disorders; leaves open whether non-intronic miR-499 influences human phenotypes.

PICO

E
Exposure / Comparator
Evolutionary and expression analysis of MYH14 and miR-499
O
Primary Outcome
Evolutionary history and expression patterns of MYH14 and miR-499

Limitations

  • Information on certain fish groups (Osteoglossomorpha, Elopomorpha, Clupeomorpha, and Protacanthopterygii) was not reviewed.
  • Experimental proof is required to confirm whether miR-499 requires drosha processing.

Cite This Study

Bhuiyan et al. (2013) studied this question. Evolutionary and expression analysis of MYH14 and miR-499 was evaluated on Evolutionary history and expression patterns of MYH14 and miR-499. Medaka miR-499 is expressed in a muscle-specific manner despite the complete evolutionary loss of its ancestral host gene MYH14, indicating the conversion of an intronic to a non-intronic miRNA.

synapsesocial.com/papers/6a9c351890ddd57cf2908e16https://doi.org/10.1186/1471-2148-13-142
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