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November 28, 2025BiologyOpen Access

The Mutation of myomiR miR499 Impacts the Intermuscular Bones in Zebrafish

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Authors

JCJinyuan CheYFYidong FengHLHaichuan Li

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Overview

Investigation reveals miR499's role in altering skeletal development and muscle activity in teleost zebrafish.

Key Points

  • Muscle activity influences the skeleton, with miR499 mutation leading to reduced ossification rates.
  • The ossification area in intermuscular bones decreased by 27%, revealing the relationship between muscle and bone development.
  • Using CRISPR/Cas9, a mutant fast-twitch muscle phenotype was developed to study intermuscular bone ossification processes.
  • Findings suggest that miR499 acts as a genetic target for enhancing aquaculture practices focused on skeletal development.

Cite This Study

Che et al. (2025) studied this question.

synapsesocial.com/papers/6928f106a65b730b9ea79afbhttps://doi.org/10.3390/biology14121670
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Mutation of myomiR miR499 Impacts the Intermuscular Bones in Zebrafish2025
  2. 2The Mutation of piezo1 Weakens the Intermuscular Bones in Zebrafish and Crucian Carp2025
  3. 3Evolution of the myosin heavy chain gene MYH14 and its intronic microRNA miR-499: muscle-specific miR-499 expression persists in the absence of the ancestral host gene2013 · 26 citations
  4. 4Integrated analysis of miRNAs-mRNAs in skeletal muscle development revealed that novel-miR-766 affects myoblast differentiation and myofiber-type formation in sheep2025
  5. 5Dynamic expression and differential requirement of the myocyte fusogen Myomixer during distinct myogenic episodes in the zebrafish2025