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November 8, 2025International Journal of Molecular SciencesOpen Access

The Mutation of piezo1 Weakens the Intermuscular Bones in Zebrafish and Crucian Carp

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Authors

XZXinyu ZhangJCJinyuan CheZLZhuang Li

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Overview

Knockout of piezo1 alters intermuscular bone development in zebrafish and crucian carp, indicating mechanosensory functions are essential.

Key Points

  • The research investigates the role of Piezo1 in intermuscular bone development in zebrafish and crucian carp.
  • Investigated Piezo1 expression in zebrafish myoseptum
  • Employed CRISPR/Cas9 to knockout piezo1
  • Conducted comparative knockout experiments in crucian carp
  • Piezo1 knockout resulted in shorter and smaller intermuscular bones in zebrafish
  • Similar effects were observed in crucian carp
  • Piezo1 is established as a key regulator of intermuscular bone development

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69253a35c0ce034ddc357beehttps://doi.org/10.3390/ijms262210851
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Localization of Piezo 1 and Piezo 2 in Lateral Line System and Inner Ear of Zebrafish (Danio rerio)2024 · 7 citations
  2. 2The Mutation of myomiR miR499 Impacts the Intermuscular Bones in Zebrafish2025
  3. 3The Mutation of myomiR miR499 Impacts the Intermuscular Bones in Zebrafish2025
  4. 4The Role of Piezo-Type Mechanosensitive Ion Channel Component 1 in Inflammatory Bowel Disease2025 · 4 citations
  5. 5Piezo1 in intestinal smooth muscle cells: Emerging perspectives2025