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December 4, 2025Biology OpenOpen Access

Dynamic expression and differential requirement of the myocyte fusogen Myomixer during distinct myogenic episodes in the zebrafish

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Authors

TSTimothy E. Saunders

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Overview

Observational analysis shows myomixer impacts multinucleated muscle formation in zebrafish, indicating its role in muscle regeneration and morphogenesis.

Key Points

  • Muscle regeneration and morphogenesis involve the myomex fusogen, affecting myocyte and tissue structure.
  • Notable changes in myotome shape were observed following myomixer loss in zebrafish during development.
  • Analysis used knockout strains to assess differential impacts of myomixer and myomaker on muscle growth.
  • Results suggest a significant interplay between fusogens and bone development in adults, highlighting varying phenotypic severities.

Cite This Study

Timothy E. Saunders (2025) studied this question.

synapsesocial.com/papers/6930dc81ea1aef094cca2609https://doi.org/10.1242/bio.062305
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamic expression and differential requirement of the myocyte fusogen Myomixer during distinct myogenic episodes in the zebrafish2025
  2. 2Differentially expressed fusogens specify myocyte states to drive myogenesis2025
  3. 3Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis2020 · 168 citations
  4. 4Myogenin is an Essential Regulator of Adult Myofibre Growth and Muscle Stem Cell Homeostasis2020 · 3 citations
  5. 5A change in <i>cis</i>-regulatory logic underlying obligate versus facultative muscle multinucleation in chordates2024 · 2 citations