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September 23, 2025Open Access

Dynamic expression and differential requirement of the myocyte fusogen Myomixer during distinct myogenic episodes in the zebrafish

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Authors

SDSunandan DharSTS. ThomasHYHui Li Yeo

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Overview

Analysis of myomixer reveals its role in myocyte fusion and muscle growth in zebrafish development.

Key Points

  • Mymx demonstrates varying expression during early myogenesis, impacting myocyte fusion and muscle structure.
  • Loss of Mymx results in disrupted myotome morphogenesis and altered skeletal muscle formation.
  • Differential impact of Mymk and Mymx mutations shows distinct roles in muscle growth and repair mechanisms.
  • Alterations to adult muscle size and strength in zebrafish affect bone development, indicating broader implications.

Cite This Study

Dhar et al. (2025) studied this question.

synapsesocial.com/papers/68d4739d31b076d99fa6bba0https://doi.org/10.1101/2025.09.22.677747
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamic expression and differential requirement of the myocyte fusogen Myomixer during distinct myogenic episodes in the zebrafish2025
  2. 2Differentially expressed fusogens specify myocyte states to drive myogenesis2025
  3. 3Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis2020 · 168 citations
  4. 4Myogenin is an Essential Regulator of Adult Myofibre Growth and Muscle Stem Cell Homeostasis2020 · 3 citations
  5. 5A change in <i>cis</i>-regulatory logic underlying obligate versus facultative muscle multinucleation in chordates2024 · 2 citations