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September 18, 2025DevelopmentOpen Access

Differentially expressed fusogens specify myocyte states to drive myogenesis

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Authors

SNSarah NahléAJAwais JavedLJLoïck Joumier

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Overview

Single-cell RNA sequencing uncovers myocyte populations influencing primary and secondary myogenesis, suggesting a complex regulatory mechanism.

Key Points

  • Two distinct myocyte populations drive primary and secondary myogenesis, challenging existing models of muscle precursor uniformity.
  • Single-cell RNA sequencing identified populations Mc1, expressing Myomaker and Myomixer, and Mc2, expressing only Myomaker.
  • Lineage tracing shows that Mc2 myocytes originate from the more complex Mc1 population during muscle fiber formation.
  • Regulatory factors Mef2 and Rxr modulate the expression of Mymx, influencing the transcriptional activity of key muscle genes.

Cite This Study

Nahlé et al. (2025) studied this question.

synapsesocial.com/papers/68d462b631b076d99fa61be4https://doi.org/10.1242/dev.204771
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamic expression and differential requirement of the myocyte fusogen Myomixer during distinct myogenic episodes in the zebrafish2025
  2. 2Dynamic expression and differential requirement of the myocyte fusogen Myomixer during distinct myogenic episodes in the zebrafish2025
  3. 3Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis2008 · 109 citations
  4. 4A change in <i>cis</i>-regulatory logic underlying obligate versus facultative muscle multinucleation in chordates2024 · 2 citations
  5. 5A change in<i>cis</i>-regulatory logic underlying obligate versus facultative muscle multinucleation in chordates2024