Key result
In healthy adults, the diurnal variation in insulin sensitivity (evening minus morning steady-state plasma glucose) was significantly greater following human growth hormone administration (38.8 mg/dL) compared to octreotide (-16.2 mg/dL).
Why the study?
Does growth hormone or octreotide alter diurnal variation in insulin sensitivity in healthy adults?
RCT (n=8)
random order
No
Does growth hormone or octreotide alter diurnal variation in insulin sensitivity in healthy adults?
Answers are grounded in this paper and cite their sources.
In healthy adults, insulin sensitivity is decreased in the evening compared with the morning, likely due to the nocturnal surge of growth hormone affecting the metabolic clearance rate of insulin and nonesterified fatty acid metabolism.
The purpose of this study was to investigate the involvement of growth hormone in the diurnal variation of insulin sensitivity in healthy adults. Afternoon (16:00 hr) or night (23:00 hr) pretreatment with a subcutaneous injection of normal saline, human growth hormone to mimic the normal nocturnal rise in growth hormone, or octreotide to inhibit endogenous growth hormone secretion to create a state of relative nocturnal growth hormone deficiency, was given 16 hours before undergoing the modified insulin suppression test in healthy subjects. The morning and evening experiments were separated by an interval of at least 3 days. Thus, each subject was tested on six separate occasions arranged in a random order. A higher value of the steady-state plasma glucose (SSPG) is indicative of lower insulin sensitivity. Plasma glucose, serum insulin, insulin-like growth factor-1, nonesterified fatty acids (NEFA), and metabolic clearance rate of insulin (MCRI) were measured. In the normal saline and human growth hormone groups, SSPG levels were lower in the morning than in the evening. Evening SSPG levels, MCRI, and NEFA concentrations were higher in the participants treated with normal saline and growth hormone than in the octreotide group. Differences in SSPG levels between the morning and evening values were higher in the participants pretreated with normal saline and growth hormone than in those treated with octreotide. A diurnal variation in insulin sensitivity existed in healthy subjects. These results provided direct evidence that the role of growth hormone in regulating insulin sensitivity might be related to changes in the MCRI and the metabolism of NEFA in healthy subjects.
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Shih et al. (2015) conducted an RCT in Healthy adults (n=8). Human growth hormone vs. Octreotide or Normal saline was evaluated on Difference in steady-state plasma glucose (SSPG) between evening and morning (p=<0.017). In healthy adults, the diurnal variation in insulin sensitivity (evening minus morning steady-state plasma glucose) was significantly greater following human growth hormone administration (38.8 mg/dL) compared to octreotide (-16.2 mg/dL).
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