Key result
An mRNA-dependent reticulocyte cell-free protein synthesizing system efficiently translated myosin heavy-chain mRNA from rat myogenic cells, representing 17% of total protein synthesis.
Population
Rat myogenic cell line (L6E9) and reticulocyte cell-free protein synthesizing system
Comparison
Cell-free translation system using K+ and Cl… vs Other cell-free translational systems
Design
Preclinical
Authors
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No immediate clinical implications; leaves open further mechanistic research on myogenic differentiation.
A novel cell-free translation system demonstrates that growing myoblasts contain high amounts of translatable myosin heavy-chain mRNA, contrary to findings from other systems.
Benoff et al. (1979) studied this question. mRNA-dependent reticulocyte cell-free protein synthesizing system vs. other cell-free translational systems was evaluated on myosin heavy chain synthesis as a percentage of total protein synthesis. An mRNA-dependent reticulocyte cell-free protein synthesizing system efficiently translated myosin heavy-chain mRNA from rat myogenic cells, representing 17% of total protein synthesis.
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