Key result
Phenylephrine matches ephedrine for maintaining BP during caesarean spinal anesthesia but acts faster.
Why the study?
Spinal anaesthesia for caesarean section can cause rapid onset of maternal hypotension with detrimental effects, and non-pharmacologic measures are incomplete, requiring vasopressors to correct hypotension quickly.
Does phenylephrine compared to ephedrine improve maintenance of maternal blood pressure in parturients undergoing caesarean section under spinal anesthesia?
Does phenylephrine compared to ephedrine improve maintenance of maternal blood pressure in parturients undergoing caesarean section under spinal anesthesia?
Both phenylephrine and ephedrine effectively maintain maternal blood pressure during spinal anesthesia for caesarean section, though phenylephrine has a faster onset and shorter duration of action.
Answers are grounded in this paper and cite their sources.
Both agents maintain maternal BP in caesarean spinal anesthesia; phenylephrine's faster onset is hypothesis-generating and should not yet change practice.
Introduction: Spinal anaesthesia has become a popular technique for caesarean section. It however has the potential to cause rapid onset of maternal hypotension which may have detrimental maternal and neonatal effects. Thus, a number of strategies for treating hypotension have been investigated. Careful positioning and volume preloading with crystalloid or colloids have been used to prevent it, but these are not complete measures and vasopressor is required to correct hypotension quickly . Methodology: 100 parturients ASA I and II scheduled for elective as well as emergency Caesarean section under sub arachnoid block (SAB) were studied. All parturients were at term, had uncomplicated singleton pregnancy with cephalic presentation. Results: Phenylephrine and Ephedrine are effective given prophylactically IV bolus followed by infusion in maintenance of arterial pressure within 15% limit of baseline. Phenylephrine has quicker and shorter duration of action effect in comparison to Ephedrine. Conclusion: Vasopressor drugs Phenylephreine and Ephedrine, effectively maintained arterial blood pressure during spinal anaesthesia for caesarean section
No takes yet. Share an insight, caveat, or question.
Prakash et al. (2021) studied Maternal hypotension during spinal anesthesia for caesarean section (n=100). Phenylephrine vs. Ephedrine was evaluated on Maintenance of arterial pressure within 15% limit of baseline. Phenylephrine and Ephedrine effectively maintained arterial blood pressure within 15% of baseline during spinal anesthesia for caesarean section, with Phenylephrine having a quicker onset.
Synapse has enriched 10 related papers. Consider them for comparative context: