December 1, 1995Journal of Hypertension
Duration of inhibition of local microvascular ACE in spontaneously hypertensive rats
Key result
Trandolapril provided the greatest duration of microvascular ACE inhibition among the tested ACE inhibitors, with significant inhibition persisting 48 hours after the last dose.
Why the study?
Does trandolapril, enalapril, or perindopril provide longer duration of local microvascular ACE inhibition in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats
Comparison
Trandolapril, enalapril, and perindopril… vs Untreated spontaneously hypertensive rats and…
Design
Preclinical
Follow-up
Up to 48 hours after the last dose
Authors
Discussion
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Implication
Trandolapril's prolonged microvascular ACE inhibition in hypertensive rats is hypothesis-generating; clinical translation remains untested.
Structured PICO
Does trandolapril, enalapril, or perindopril provide longer duration of local microvascular ACE inhibition in spontaneously hypertensive rats?
P
Population
Spontaneously hypertensive rats treated with oral ACE inhibitors for 2 weeks to assess the duration of local microvascular ACE inhibition.
I
Intervention
Trandolapril (0.6 mg/kg per day), enalapril (10 mg/kg per day), and perindopril (2 mg/kg per day) administered orally by gavage for 2 weeks
C
Comparator
Untreated spontaneously hypertensive rats and comparison among the three ACE inhibitors
O
Outcome
Local ACE activity estimated by measuring vasoconstriction in response to 0.01 and 0.1 nmol/ml angiotensin I in arteriolessurrogate
Trandolapril provides a longer duration of local microvascular ACE inhibition compared to enalapril and perindopril in spontaneously hypertensive rats.
Cite This Study
Vicaut et al. (1995) studied Hypertension (spontaneously hypertensive rats). Trandolapril, enalapril, and perindopril vs. Untreated spontaneously hypertensive rats and each other was evaluated on Local ACE activity estimated by measuring vasoconstriction in response to angiotensin I. Trandolapril provided the greatest duration of microvascular ACE inhibition among the tested ACE inhibitors, with significant inhibition persisting 48 hours after the last dose.